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An integrated platform for European paediatrics based on a Grid-enabled network of leading clinical centres To gain a comprehensive view of child's health by vertically integrating biomedical data, information and knowledge that spans the entire spectrum from genetic to clinical to epidemiological. To develop a biomedical information platform, supported by sophisticated and robust search, optimisation and matching techniques for heterogeneous information, empowered by the Grid To build enabling tools and services on top of Health-e-Child platform, that will lead to innovative and better healthcare solutions in Europe Integrated disease models exploiting all available information levels Database-guided biomedical support systems enabling novel clinical practices and personalised healthcare for children Large-scale, cross-modality and longitudinal information fusion and data mining for biomedical knowledge discovery