Bio-oriented technologies became very popular in various research topics and industrial market segments. Current human mechanisms seem to offer significant ways for improving theories, algorithms, technologies, products and systems. A myriad of theoretical models, dedicated software solutions, and mathematical algorithms and calculi helps improving gathering and representing knowledge on human being. Bioengineering and biomedical computation and representation techniques rely on special biocomputing techniques inspired from this process. Bioinformatics itself constitutes a vast area of research and specialization, as many classical domains such as databases, modeling, and regular expressions are used to represent, store, retrieve and process a huge volume of knowledge. Large scale biosystems opened the need for specific devices, such as biomechanical, biorobotics, nanosensors, human-oriented control systems, etc. As progress is extremely fast, there is a continuous need to keep pace with the developments and achievements, as well as with challenging issues. BIOTECHNO brings together achievements and challenges for practical software and hardware support, highlighting the advances in biocomputation, bioinformatics, and biomedical technologies.