Informational

Modafinil vs Adrafinil. A professional analysis from experts

According to Google trends, over the past few years, the level of smart drugs popularity has grown by around 15-20 points. If we examine the information about Modafinil requests, we will discover these numbers:

  • Up until 2015, the level of request frequency related to this drug was around 40-45 points.
  • Starting with 2015 to the present day, the level of Modafinil popularity is 65-70 points.

Modafinil is very popular among young people and businessmen. It helps activate enhanced brain performance and makes you think faster. But many have forgotten that 10 years ago, the most popular “smart drug” was Adrafinil. This solution first appeared in the pharmaceutical market and caused a revolution. Even until now, it is considered the number 1 drug among all nootropics in many countries of the world.

Modafinil and Adrafinil are related to each other, and there are more things in common between them than you might think. But there are also a few key differences that we’ll talk about today.

Adrafinil overview

Adrafinil is a synthetic nootropic drug that works as a central nervous system stimulator. It prevents fatigue, increases energy levels and the period of alertness. It also improves mood, motivation, and concentration.

This substance was synthesized by the French company Lafon Laboratories (it is now known as Cephalon) in the 1970s. Scientists have discovered the unique properties of this new substance. It caused alertness, supplemented energy and improved mental capabilities. After experimental studies, it was found that Adrafinil can be used to treat narcolepsy (a condition in which excessive daytime sleepiness occurs).

In 1986, Adrafinil was released under the Olmifon brand name. Up until now, it is sold under the same brand name.

Modafinil overview

For many years, Adrafinil was the only nootropic drug that met high standards of safety and efficacy. But the clinical studies of this substance did not cease for a single minute. As scientists found out from Lafon, Adrafinil was only a prodrug.

All by itself, this substance has no pharmacological action and Modafinil, the main active metabolite, is responsible for the result. After penetrating the biological environment (in our case, the human body), Adrafinil turns into Modafinil and only after that the action starts to take place.

After the researchers managed to isolate the active molecule, they created Modafinil’s formula. This substance was released on the market under the Provigil brand name.

During the first few years, Modafinil became much more popular than its older brother. It was much more powerful and interesting in terms of additional effects. Only with the appearance of Modafinil, it became clear that this is more than a cure for narcolepsy. Nootropics began to be used as “cognitive enhancers” by all people whose work is associated with mental activity.

Purchasing Adrafinil and Modafinil

It may be easier for you to buy Adrafinil because it is sold even on Amazon. Finding a store in the USA and Canada would not be difficult at all. However, Adrafinil does not have generics, so the price of each tablet will be too high.

The original version of Modafinil is sold under the Provigil brand name. This is also an expensive modification of the drug. It cannot be bought without a prescription, and the doctor will write you a prescription-only if you have narcolepsy or any other serious indications for use.

Instead of looking for a doctor who will give you a prescription for Adrafinil or Modafinil, we recommend that you find a good seller of generic versions.

There are certified ehealth pharmacy and afinil Express shops where you can buy Modalert, Modvigil, Walkert 150mg and other cheap versions of nootropics. You don’t need a prescription from a doctor. Parcels are sent worldwide.

But before you make an order in the online store you need to learn as much as possible about each drug and compare their value for your purpose.

A detailed comparison of Modafinil vs Adrafinil

Perhaps we will start with the common aspects between Modafinil and Adrafinil. These substances have an identical mechanism of action and similar pharmacological properties:

  • They increase the production of dopamine, histamine
  • Increase the level of noradrenaline in blood
  • Suppress drowsiness and invigorate
  • Increase mental and physical performance

Their general properties are very similar, but we are more interested in their differences. As soon as we began to explore the properties of each drug and user reviews, we noticed how many differences they have.

The key differences between Adrafinil and Modafinil. What do you need to know?

  1. Half-life

The therapeutic response to the action of the drug depends on this indicator. The body processes Adrafinil within an hour, after which it turns into Modafinil. It takes about 2 hours for the molecule to start working. This means that after taking the pill of Adrafinil, you will not feel any effect for about 2-2.5 hours.

Maximum effect occurs after around 4-5 hours when there is the highest concentration of Modafinil in blood. If we talk about a pure modafinil molecule, then it starts to work after about 1-1.5 hours. In other words, the peak therapeutic effect is achieved after 2-2.5 hours.

  1. Adrafinil is a prodrug

Adrafinil starts working later because it is a prodrug. To be precise, it is an inactive chemical substance that is converted in the body into an active metabolite. You lose a couple of hours only because the active ingredients don’t immediately go into the active phase. However, prodrugs have something else to offer. Their action lasts a little longer. Therefore, you must choose what you need – a quick effect of Modafinil, or an additional 1-2 hours of Adrafinil effect.

  1. Liver safety

Many are concerned that Adrafinil is converted to Modafinil in the liver. Additional enzymes are produced in the liver for this process. This is a natural process that occurs regularly. But this should not be a reason for worry for people with a healthy liver.

But if you have any functional changes in the liver, you should choose a safer Modafinil. Its molecules also break down in the liver, but this requires several times fewer enzymes.

  1. Efficiency and safety

In the process of transformation of Adrafinil to Modafinil, about 40-50% of the active components are lost. To be exact, you need to take a dose of 400 mg of Adrafinil to get the same effect as taking Modafinil 200 mg. This is an additional problem for the liver.

Because of this, the pharmacological safety index of Modafinil is much higher.

Also, insomnia frequently becomes an issue because of the higher dosages of Adrafinil. Identifying the appropriate dose is much more difficult also because many patients cannot avoid side symptoms.

  1. Availability

In our opinion, Adrafinil has one big advantage – its sale is not regulated in most countries. Some continue to use this modification because they do not know where to buy Modafinil.

In some countries, Adrafinil is sold in pharmacies without a prescription. As a result, you can simply go outside, walk to the nearest drugstore and ask for a package of pills. With Modafinil everything is more complicated. By using websites like ModUP Afinil Express you can buy Modafinil on the Internet and pay for your order using Bitcoin. That’s fast, convenient and accessible all around the world.

Conclusion: which drug to select and why?

We hope that the basic information will help you decide. Although it is easier to buy Adrafinil, it has many drawbacks. We would recommend you to buy more modern versions of Modafinil and Armodafinil. No wonder that the official manufacturer Cephalon stopped selling Adrafinil in 2011 because it was considered to be an outdated version. This is a good drug that does not stand the competition in the current situation.

Informational, Product Guide

Modvigil vs Modalert: Why are They Different?

Modvigil vs Modalert Drug Comprassion

Modafinil has been available in generic form since 2010 and you can buy modafinil online. In the last few years dozens of companies have stepped up to produce their own generic version of Modafinil.

You might be confused when you see the laundry list of names that are out there:

  • Alertec
  • Alertex
  • BravaMax
  • Carim
  • Provake
  • Mentix
  • Modasomil
  • Modavigil
  • Modalert
  • Modapro
  • Modafil
  • Modvigil
  • Modatec
  • Modiodal
  • Provigil
  • Resotyl
  • Stavigile
  • Vigia
  • Vigicer
  • Vigil
  • Zalux

Don’t be, they are in fact one and the same.

Once a patent for a drug expires any pharmaceutical manufacturer can produce it. Modafinil had become quite popular, and so many companies all over the world sought to produce their own version of generic Modafinil. Many of the above names are catered to a local market or language to improve sales. Regardless of what name they have, they are essentially the same exact thing.

Generic medicines are made by following the recipe outlined in the original patent. Think of it like baking a cake. The original brand-name manufacturer made the first cake, and patented its ingredients and methods. Now that information is available to the public, and anyone can make the same cake. The FDA regulates the generic medicine (or cake) market to ensure that the product you receive matches the original brand-name product. If the brand-name product created a “Chocolate Raspberry Layer Cake” then the generic version must also be the same exact flavor.

What makes generics different is that they are able to use different quality ingredients, or in some cases different quantities of those ingredients to make their cake. Perhaps one manufacturer uses 100% dark chocolate from Brazil, while another uses a cheaper 90% semi-sweet chocolate from Asia. One factory uses premium flour and sugar while another decides to use an artificial sweetener. The cakes will have the same basic flavor, but they won’t be exactly the same. Some might be a little better than others.

Modvigil vs Modalert: Generics or Brand

Generics can also use different packaging. One company simply wraps his cake in clear plastic to save some money, while another puts it in an elegant box. The packaging doesn’t affect the taste, just the presentation.
Ultimately this explains the differences in price between generic medicines. The only difference between generic medicines is the ingredients used to make them and the way they are packaged. Generics are always cheaper than brand-name drugs because the generic maker didn’t have to invest in research, testing, or marketing.

Are generics effective?

But are generics really effective? The FDA requires that all generic medicines contain 85-128% of the brand name’s active ingredient. This means that generics may sometimes be a bit weaker than the original formula, or they could even be a bit stronger. But in general they must fall within that range. All generics, regardless of their brand, contain the same primary ingredient and roughly the same amount.

So why do some people boldly claim that one generic is more effective than other, while other people declare the exact opposite? Based on what has just been said, it’s completely possible that some generics contain more of the active ingredient than others. However if that were the case, there wouldn’t be a debate. People should unanimously agree that one generic is superior.

One of the reasons why users frequently disagree about which generic is better is due to the “Brand Name Placebo Effect.”

This effect occurs when people believe that the drug they have taken is working better due to its name, cost, or packaging. Names matter. There’s a reason why companies spend millions on marketing trying to come up with the best way to sell their product. Have you ever seen an energy drink named “Sleepy Time”? The price matters too. When we pay more for something, we want to justify that increase in price. A pill that costs $4 MUST work better than one which costs $1, right? When something is well packaged, we perceive it as better. Why else would high-end restaurants decorate their plates and spend so much time making them look appetizing? That sprig of parsley doesn’t make the food taste better, it only looks better.

Where to Buy Modvigil or Modalert?

What really matters is if the generic is tested and safe. One problem with generics is that many of the factories are located in different countries where testing standards and inspections are not as well enforced. The only generic to have been subjected to a battery of tests Modvigil, which is sold by Canadian Pharmacy. Every batch is tested to ensure that it contains a high quantity of Modafinil, nothing more and nothing less. This guarantees your safety, which should be your primary concern any time you put something into your body. Modvigil’s packaging has also been praised as being high quality compared to other brands.

 

Informational

Modafinil Dosage Guide: 200mg – 400mg – 600mg – 800mg

Modafinil is a eugeroic substance, which means that it affects the sleep-wake cycle, or circadian rhythm. The drug is prescribed in a number of health conditions linked to circadian rhythm disruptions, as well as the lack of concentrating ability, but its mechanism that is based on inhibiting somnolence hormones has found another application which is much more popular than the on-label use of Modafinil. Modafinil is a powerful “smart” and “wake” psychostimulant drug used by heavy-duty performers: top-tier managers, students, people who work nightshifts and anyone in need of staying alert and focused for a specified period of time.

All you need to know about Modafinil

Modafinil is intended for adults for the treatment of severe sleepiness associated with narcolepsy with or without cataplexy. Pronounced sleepiness is defined as the difficulty of staying awake and increasing the likelihood of falling asleep on inappropriate occasions. Treatment should be initiated or monitored by a physician with special experience in the indicated conditions.

Modafinil, Ritalin and Adderall are amphetamines that have the task of stimulating the central nervous system. Originally created to treat ailments such as narcolepsy and attention deficit syndrome (ADHD), in some cases they are improperly used by individuals who are not affected by the aforementioned pathologies, who wish to improve their cognitive performance, because their potential is translated in higher concentration levels. The phenomenon seems to be growing, although specific research has not yet been conducted, so the percentages and demographic characteristics of consumers are not yet known.

Modafinil dosage: 200mg vs 400mg

There are several dosage forms available for Modafinil, each of them applicable in particular conditions and for specific purposes. The tablets are designed for oral use. The tablets should be swallowed whole.

In ADHD and narcolepsy, the recommended starting dose is 200 mg daily. The total daily dose can be taken either as a dose in the morning or divided into two occasions, one in the morning and one in the middle of the day after the doctor’s assessment of the patient and the response. Doses up to 400 mg in one dose or two divided doses may be given to patients in whom the initial 200 mg Modafinil dose is insufficient.

Many Modafinil users are healthy individuals who have intentionally used these medicines to maintain concentration for long periods of time. These people are referred to as “cognitive enhancers”. The first few times they used Ritalin and Adderall, then, frightened by the particularly intrusive side effects (tachycardia, hypertension, hyper-sweating), they all switched to Modafinil  Modalert, drugs similar to the previous ones, but with less obvious physical repercussions. Since they are prescription drugs, the only way to circumvent the law is to buy on the internet, where they are at very low prices. The effect of a whole tablet lasts 8 to 10 hours, helps maintain concentration and “perform” longer.

For the purposes of increasing alertness, mood stabilizing, anti-psychotic and psychoneuroimmunological purposes, Modafinil is recommended to be taken according to the following pattern:

  • 400 mg during 24 hours
  • 1 tablet of Modafinil 200 mg in the morning
  • 1 tablet of Modafinil 200 mg during lunch time

The benefits expected from this posological pattern are as follows:

  • “Inhibited” fatigue
  • Increased alertness and wakefulness
  • Elevated mood
  • Better focusing abilities
  • Boosted motivation
  • Improved cognitive abilities
  • Augmented memory resources
  • “Focused” calmness
  • Improved ability of driving and operating machinery

Modafinil OTC

While Modafinil is a prescription drug in the US, it is readily available in its generic forms without prescription, on “over the counter” basis. The authorities turn a blind eye to recreational use of Modafinil for “pharmaceutical cognitive enhancement” – the widespread phenomenon where medically prescribed drugs are used for improving cognitive functions in healthy individuals. A whole generation of students and entrepreneurs, however, certifies its use as a smart drug, or a compound to improve attention, motivation, learning and memory.

As a MPP (medically prescribed psychostimulant), Modafinil cannot be sold OTC at the pharmacy chains, but it can be ordered online safely and inexpensively. A leading supplier of Modafinil online is Canadian Pharmacy – a reliable e-store specializing in satisfying customer demand for illicit psychostimulants with verifiable safety. The benefits of using the services of Canadian Pharmacy are safety and anonymity of order, as well as fast delivery and low price for Modafinil.

The users, interviewed at the request of anonymity, say they are satisfied with the results obtained and express the desire to continue using these drugs in the future, in particular Modafinil.

How to buy Modafinil online

Smart drugs, also called nootropic drugs (noos = mente and tropein = surveillance) are substances that increase the cognitive abilities of human beings. Today there are hundreds of drugs used in humans to improve their cognitive substances. Every year new molecules are synthesized, which are then sold on the internet in the form of tablets. Many of these, following pharmacological analyzes, are declared illegal by the Ministry of Health. Some, however, cannot be considered illegal, because they are medicines. Modafinil is one of such drugs.

Modafinil is approved by the Federal Drug And Food Association as safe for an unregulated and free use in anyone wanting to improve their alertness; the study of the drug’s safety is available on the official site of NCBI.

Given all of the above, Modafinil can be bought off an online store with a reputable name to it – search forums like Quora or Reddit to find out about the sources or check out the e-shop referred to above – in a hassle-free manner. Clicking your Modafinil pills home saves time, efforts and money, but more importantly – you will not have to produce a prescription for the drug. While it is not possible to buy Modafinil without prescription off a brick-and-mortar pharmacy, you can buy generic version Modafinil online in just a few clicks quite safely and legally.

 

Informational

Limitless Pill – NZT-48 – What is Сommon with Modafinil?

NZT-48 – God Mode

Would you like to have a super-power? For example, an abnormal memory and maximum concentration? You will probably say “yes”. But may will say that it is impossible. Even if the cognitive abilities are developed since childhood, a limit will happen sooner or later.

There is an assumption that the human brain does not work for 100%. Various information is met in various sources. Some scientists state that the human brain works just for 5-6%, others say 10%, and the progressive people are able to use 20% of the brain. In fact, there is a grain of truth in all these statements.

Limitless Movie

nzt-48A movie Limitless was made about a magical pill NZT-48. This pills stimulated the concealed abilities of the brain and opened a world for the human. After this movie, NZT-48 has become very popular, but it does not exist.

NZT-48 was specially invented to show the abilities of the brain activated by certain chemical ingredient. Using NZT-48 a human could learn language within a short period, develop mathematical and analytical abilities, solve difficult tasks, make decisions in a short period. Under the action of NZT-48, you would have super-power, your brain would quickly process information and use it for its purposes. Even if you saw or heard something some time, NZT-48 would make your brain to recollect it and use it as needed.

In fact, the appearance of NZT-48 would cause an excitement and a great demand for this medicine. Every person would like to have the advantages before others and activate the concealed brain functions. But NZT-48 would not be developed soon. And here is a reason. If you watched the movie, you probably know that the characters had severe side effects after the finished action of the pill. These side effects are reasonable because the brain is not able to work non-stop, 365 days. Sooner or later, the human will have a breakdown and severe disorders. These facts stop most people, and they perhaps will not try NZT-48.

And now, let us imagine that a drug acting like NZT-48 has entered the market and been licensed and passed medical studies, and it almost does not cause side effects. You do not know but such medicine already exists.

Analogue of NZT-48

Modafinil is an analogue of NZT-48 which has been developed for the medical purposes. If NZT-48 was developed to increase the higher functions of the brain, Modafinil has been initially developed for the treatment of the pathological sleepiness. Only in several years, scientists have found out that Modafinil has unique characteristics and is able to increase the cognitive functions.

Modafinil acts like NZT-48. It also influences on the motion of the electric impulses in the brain, stimulates the production of the chemical ingredients responsible for the higher brain functions and improves a nutrition of the brain tissues. It all helps to increase the working ability and make a human more concentrated.

But unlike NZT-48, Modafinil is completely safe. It is surprisingly but FDA has approved Modafinil and even recommend it patients with many disorders (attention deficit disorder, multiple sclerosis, mental disorders, and others).

Modafinil does not cause a medical addiction. And if people had side effects after the use of NZT-48, it will not happen with Modafinil.

A high pharmacological safety does not allow to achieves such results as during the use of NZT-48. It is a fact. You are not able to learn a foreign language in a month just due to Modafinil. But a general working capacity of the brain is increased. Every human feels the action of Modafinil in a different way, because everybody has various purposes, goals and a development of the brain. But in general, if you want to obtain new skills, or cope with difficult tasks, Modafinil is what you need.

Informational

Modafinil Side Effects and What You Need to Know

The American psychiatrist James J. McGough assumes that employers would prefer employees who take cognitive boosters including Modafinil. “Any chief would like to have a Hulk-employee who would work 16 hours and would not let down.”

This loud statement has its grounds because a human is able to work longer, faster and more effectively under the action of Modafinil. But won’t employers regret their choice? Any psychostimulant, even the safest one has side effects. After a “burst” of the mental abilities, a recession happens.

In order to find this out, it is necessary to know how often the side effects appear during the use of Modafinil and how dangerous they are for a human.

Most scientists state that Modafinil is safer than all known psychostimulants. This is really so. It does not cause a medical addiction (during the proper application) and does not cause complications of the mental/cardiovascular diseases.

 

Scientists from Harvard and Oxford have called Modafinil “the first safe smart-drug in the world”. They assume that if it is used for a short period, a risk will be low. But it is impossible to find real statistics of those who take the drug (people do not confess to taking doping). Even if it is safe. But there is still data about the pharmacological safety of Modafinil.

There is data that about 30% of people taking Modafinil face headaches. When the drug stops acting, a short-term headache of different intensity occurs. This side effect is peculiar to many medical products but it cannot be ignored. Therefore, if you are not afraid of headache, you may start taking Modafinil.

Modafinil activates the hidden abilities of the body. the brain works non-stop, 24/7. Thus, it cannot last forever. Cachexia may occur during a long-term use of Modafinil. Lack of sleep and energetic exhaustion may lead to psychoses, neuroses, and other psychoemotional disorders. That is why, if you need a doping for the brain, bear in mind that the brain should rest.

Also the use of Modafinil may be accompanied by diarrhea, anxiety, high blood pressure, and dizziness. But all these side effects are temporal and usually pass during the lowered dose.

A real negative side effect of Modafinil is allergic reactions. As Modafinil lowers the level of histamine, the body becomes helpless and cannot resist the allergic reaction. Well, it resists, so that acute reactions may happen: skin rash, urticaria, itching, edema of limbs, tongue, face, and skin flaking. If your body is sensitive to the action of allergens and you are not sure that the use of Modafinil may cause an acute reaction, it is better to refuse from the use of the drug. Allergy may occur suddenly and in any form. So, if you noticed rash, itching, or edema after the use of the pills, seek for a medical aid right away.

In general, if the dosage regimen of Modafinil is controlled, and the body reaction is followed, it is possible to avoid severe side effects. And if employers need a person who works 24/7, they would not be happy to see their workers with headache and allergy. All leaves its marks. If you decided to take Modafinil, be careful.

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