According to Google trends, over the past few years, the level of smart drugs popularity has grown by around 15-20 points. If we examine the information about Modafinil requests, we will discover these numbers:

  • Up until 2015, the level of request frequency related to this drug was around 40-45 points.
  • Starting with 2015 to the present day, the level of Modafinil popularity is 65-70 points.

Modafinil is very popular among young people and businessmen. It helps activate enhanced brain performance and makes you think faster. But many have forgotten that 10 years ago, the most popular “smart drug” was Adrafinil. This solution first appeared in the pharmaceutical market and caused a revolution. Even until now, it is considered the number 1 drug among all nootropics in many countries of the world.

Modafinil and Adrafinil are related to each other, and there are more things in common between them than you might think. But there are also a few key differences that we’ll talk about today.

Adrafinil overview

Adrafinil is a synthetic nootropic drug that works as a central nervous system stimulator. It prevents fatigue, increases energy levels and the period of alertness. It also improves mood, motivation, and concentration.

This substance was synthesized by the French company Lafon Laboratories (it is now known as Cephalon) in the 1970s. Scientists have discovered the unique properties of this new substance. It caused alertness, supplemented energy and improved mental capabilities. After experimental studies, it was found that Adrafinil can be used to treat narcolepsy (a condition in which excessive daytime sleepiness occurs).

In 1986, Adrafinil was released under the Olmifon brand name. Up until now, it is sold under the same brand name.

Modafinil overview

For many years, Adrafinil was the only nootropic drug that met high standards of safety and efficacy. But the clinical studies of this substance did not cease for a single minute. As scientists found out from Lafon, Adrafinil was only a prodrug.

All by itself, this substance has no pharmacological action and Modafinil, the main active metabolite, is responsible for the result. After penetrating the biological environment (in our case, the human body), Adrafinil turns into Modafinil and only after that the action starts to take place.

After the researchers managed to isolate the active molecule, they created Modafinil’s formula. This substance was released on the market under the Provigil brand name.

During the first few years, Modafinil became much more popular than its older brother. It was much more powerful and interesting in terms of additional effects. Only with the appearance of Modafinil, it became clear that this is more than a cure for narcolepsy. Nootropics began to be used as “cognitive enhancers” by all people whose work is associated with mental activity.

Purchasing Adrafinil and Modafinil

It may be easier for you to buy Adrafinil because it is sold even on Amazon. Finding a store in the USA and Canada would not be difficult at all. However, Adrafinil does not have generics, so the price of each tablet will be too high.

The original version of Modafinil is sold under the Provigil brand name. This is also an expensive modification of the drug. It cannot be bought without a prescription, and the doctor will write you a prescription-only if you have narcolepsy or any other serious indications for use.

Instead of looking for a doctor who will give you a prescription for Adrafinil or Modafinil, we recommend that you find a good seller of generic versions.

There are certified ehealth pharmacy and afinil Express shops where you can buy Modalert, Modvigil, Walkert 150mg and other cheap versions of nootropics. You don’t need a prescription from a doctor. Parcels are sent worldwide.

But before you make an order in the online store you need to learn as much as possible about each drug and compare their value for your purpose.

A detailed comparison of Modafinil vs Adrafinil

Perhaps we will start with the common aspects between Modafinil and Adrafinil. These substances have an identical mechanism of action and similar pharmacological properties:

  • They increase the production of dopamine, histamine
  • Increase the level of noradrenaline in blood
  • Suppress drowsiness and invigorate
  • Increase mental and physical performance

Their general properties are very similar, but we are more interested in their differences. As soon as we began to explore the properties of each drug and user reviews, we noticed how many differences they have.

The key differences between Adrafinil and Modafinil. What do you need to know?

  1. Half-life

The therapeutic response to the action of the drug depends on this indicator. The body processes Adrafinil within an hour, after which it turns into Modafinil. It takes about 2 hours for the molecule to start working. This means that after taking the pill of Adrafinil, you will not feel any effect for about 2-2.5 hours.

Maximum effect occurs after around 4-5 hours when there is the highest concentration of Modafinil in blood. If we talk about a pure modafinil molecule, then it starts to work after about 1-1.5 hours. In other words, the peak therapeutic effect is achieved after 2-2.5 hours.

  1. Adrafinil is a prodrug

Adrafinil starts working later because it is a prodrug. To be precise, it is an inactive chemical substance that is converted in the body into an active metabolite. You lose a couple of hours only because the active ingredients don’t immediately go into the active phase. However, prodrugs have something else to offer. Their action lasts a little longer. Therefore, you must choose what you need – a quick effect of Modafinil, or an additional 1-2 hours of Adrafinil effect.

  1. Liver safety

Many are concerned that Adrafinil is converted to Modafinil in the liver. Additional enzymes are produced in the liver for this process. This is a natural process that occurs regularly. But this should not be a reason for worry for people with a healthy liver.

But if you have any functional changes in the liver, you should choose a safer Modafinil. Its molecules also break down in the liver, but this requires several times fewer enzymes.

  1. Efficiency and safety

In the process of transformation of Adrafinil to Modafinil, about 40-50% of the active components are lost. To be exact, you need to take a dose of 400 mg of Adrafinil to get the same effect as taking Modafinil 200 mg. This is an additional problem for the liver.

Because of this, the pharmacological safety index of Modafinil is much higher.

Also, insomnia frequently becomes an issue because of the higher dosages of Adrafinil. Identifying the appropriate dose is much more difficult also because many patients cannot avoid side symptoms.

  1. Availability

In our opinion, Adrafinil has one big advantage – its sale is not regulated in most countries. Some continue to use this modification because they do not know where to buy Modafinil.

In some countries, Adrafinil is sold in pharmacies without a prescription. As a result, you can simply go outside, walk to the nearest drugstore and ask for a package of pills. With Modafinil everything is more complicated. By using websites like ModUP Afinil Express you can buy Modafinil on the Internet and pay for your order using Bitcoin. That’s fast, convenient and accessible all around the world.

Conclusion: which drug to select and why?

We hope that the basic information will help you decide. Although it is easier to buy Adrafinil, it has many drawbacks. We would recommend you to buy more modern versions of Modafinil and Armodafinil. No wonder that the official manufacturer Cephalon stopped selling Adrafinil in 2011 because it was considered to be an outdated version. This is a good drug that does not stand the competition in the current situation.

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